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For the prevention and control of ferroptosis, we focus on the two main targets in the process of its occurrence and development: iron metabolism and lipid peroxidation

In support of this is the fact that the concentrations of biomarkers of B 12 function, methylmalonic acid and homocysteine increase in the later stages of pregnancy (Reference Murphy, Molloy and Ueland57,Reference Milman, Byg and Bergholt58) suggesting some level of metabolic B 12 depletion in pregnant women

Although GPX4 inhibitors have made significant progress in inducing ferroptosis, as an increasing number of antioxidant systems are being discovered, it is still necessary to explore other mechanisms that induce ferroptosis

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