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In an overdose, peak serum concentrations are usually achieved within 2 hours, but delayed absorption of acetaminophen occurs following overdoses of preparations in which acetaminophen is combined with propoxyphene or diphenhydramine, as well as those with altered-release kinetics such as extended-release preparations

In summary, the development of NADs has undergone a long process, with research on the mechanisms of action of different types of drugs and breakthroughs in chemical modification and delivery technologies

However, cases were assigned as non-overdose by an expert committee if there was no history of overdose and a non-toxic plasma paracetamol concentration (PPC), meaning that some of these cases may in fact have been concealed overdoses if a history of overdose was not given and enough time had elapsed for PPC to become undetectable [26]