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Eprenetapopt/APR-246/PRIMA-1 MET is a small molecule drug which has been proposed to bind to cystine residues in mutant p53, thermodynamically stabilizing it such that both WT conformation and functionality is restored [9]

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Sasaki K, Strom SS, O'Brien S, Jabbour E, Ravandi F, Konopleva M, Borthakur G , Pemmaraju N, Daver N, Jain P, Pierce S, Kantarjian H, Cortes JE

While synergistic benefits are mechanistically plausible, direct clinical trials on combined supplementation remain limited, and cost factors must be balanced against targeted outcomes