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For example, exposure to physical stimuli of suprathreshold intensitysuch as heat or mechanical forces (Gong et al., 2012) as well as oxygen deprivation (Shim et al., 2025), can upregulate HSF1 expression

A repeated-measures two-way ANOVA revealed a significant main effect of the factors treatment (F (1,16) = 12.47, P = 0.0028), time (days) (F (5,80) = 4.437, P = 0.0012), and a significant treatment time interaction (F (5,80) = 10.89, P 0.05

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