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Further longitudinal studies are required to observe if the pattern of the elevation of certain cytokines follows a similar pattern seen in ME/CSF, where some cytokines decrease after being elevated in the first years of the disease despite the persistence of symptoms [228]

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Moreover, the positive correlation between exposure to BPA and the level of MCP-1 protein can indicate the development of an inflammatory condition associated with the accumulation of this xenoestrogen

Our findings of this meta-analysis are that the beneficial effects have been shown by the increase of overall efficacy, LVEF, strike volume, cardiac output, and E/A, by the decrease of left ventricular end-diastolic diameter, left ventricular end-systolic diameter, and left ventricular end-systolic volume and serum levels of BNP and NT-proBNP, and with satisfactory safety