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Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS

267,268 Under oxidative stress conditions, Nrf2 dissociates from Keap1 following thiol modifications of its cysteine residues, preventing Nrf2 ubiquitination and proteasomal degradation

It is significant in assisting the organism to safeguard cells against oxidative stress, to detoxify the organism, and to keep the immune system healthy

A successful kefir fermentation is driven by the metabolism interaction between LAB and yeast (Smid & Lacroix, 2013)