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The ongoing assessment of the patients condition is crucial in determining the duration and frequency of therapy, making adjustments as necessary based on therapeutic response and any changes in the patients health status

Although lipid peroxidation plays a major role in mediating ferroptosis, this biochemical response to oxidative damage also occurs in other types of RCD [201,202]

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats