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If these intermediates build up faster than the Krebs cycle can process them, they become highly toxic, effectively choking the mitochondria and halting the entire energy-producing apparatus

35 The recent phase 3 Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis (ESSENCE) trial showed that semaglutide 2.4 mg once weekly improved liver histology in patients with metabolic dysfunction-associated steatohepatitis with moderate or advanced liver fibrosis

*Dependent on the extent of renal dysfunction and age of the patient

3 Ferroptosis and NAFLD 3.1 Ferroptosis and inflammation Globally, the prevalence of NAFLD continues to rise, encompassing a spectrum of conditions from simple steatosis to NASH, fibrosis, and cirrhosis (40)