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Melatonin is crucial in lowering ROS and RNS levels in mammalian sperm and embryos, which contributes to decreased peroxide concentrations and DNA damage, ultimately leading to an increase in the viability of germ and embryonic cells (Nadri et al
(2022) An Individualized Approach to Managing Testosterone Therapy in the Primary Care Setting Shi, I
Failure of these protective mechanisms increases transferrin receptor and acyl-CoA synthetase long-chain family member 4 (ACSL4) expression, enhancing lipid peroxidation and ferroptotic cell death
