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We conclude that a single nucleotide substitution was sufficient to switch the repair mechanism, relative to the substate with symmetric G:T mispairs: the ordered, semi-conservative path to repair is now dominant (model 2 favored 18:1 over model 1)

In some embodiments, a pulsed release profile is achieved by solubilizing up to 40% of the delivered dose of the therapeutic agent (e.g., micronized therapeutic agent, or free base or salt or prodrug thereof

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