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It neutralises free radicals and prevents them from causing cellular damage

(2) NMN co-treatment was conducted by adding 90 L of 250/500 M NMN for four hours prior to chemotherapy treatment, and this was performed by adding 20 L from a series of descending drug concentrations to the cell culture plate with either bleomycin, cisplatin, doxorubicin, etoposide, gemcitabine, methotrexate, paclitaxel or vincristine

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Pembrolizumab and nivolumab which have also been in a category of immune checkpoint inhibitors are approved by FDA as a first line therapy in patients having cisplatin insensitive recurrent or metastatic HNSCC [19,20,21]