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Otilimab (GSK-165) and lenzilumab (KB003, by company Kalobios ) showed a high affinity in healthier volunteers for GM-CSF and are now in phase III in RA patients, so further evaluation on a large population sample size is needed (ClinicalTrials.gov Identifier: NCT03970837, NCT04351152) [68]

Rats, similar to humans, develop age-related cognitive difficulties

Statements Data availability statement The data generated in this study can be found in ProteomeXchange: Ethics statement The animal study was reviewed and approved by Animal handling and experimentation were approved by the Laboratory Animal Care and Use Committee of the Shaanxi University of Chinese Medicine

Books (edited and written) Hunt KK, Vorburger SA, Swisher SG