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Nimbolide induces oxidative stress in fungal cells, impairing energy production and enhances macrophage and T-cell activity, helping the host clear fungal infections while reducing fungal toxin burden and systemic inflammation

Surgical Management While conservative measures are helpful, surgery is the only way to permanently repair a parastomal hernia

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Thus, observed potent induction of ferroptosis, GPX4-dependent novel suppression of mTOR pathway and DNA damage repair response in preclinical in vitro model of TC supports GPX4 targeting for therapeutic benefit in advanced therapy-resistant thyroid cancers