glutathione disulfide bonds 6. Introduction to Glutathione disulfide - Wikipedia

Potential of these effects may be heightened in patients with breast cancer treated with hepatically metabolized chemotherapeutics (e.g., cyclophosphamide, paclitaxel, anthracyclines) or tyrosine kinase inhibitors in which drug-drug interaction-based elevation or lowering of enzyme activity can result in supra-therapeutic drug concentrations, accumulation of toxic metabolites and compromised detoxification of reactive oxygen species facilitating hepatocellular distress

Linge, J., Birkenfeld, A

Ischemia leads to endothelial cell damage, blood-brain barrier (BBB) disruption, and increased permeability, allowing a large influx of iron into the brain parenchyma (Tuo et al., 2017)

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