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A 2010 New England Journal of Medicine trial by Falutz et al

In our recent research, it has been seen that at low concentration of 5-ALA (5 g/mL) and low irradiation energy density of 1 J/cm 2 (low-dose PDT) in both normal and diabetic cell models caused a slight increase in ROS levels compared to control groups which lead to better wound closure in those group

For instance, the FXR agonist obeticholic acid (OCA) has been demonstrated to attenuate systemic inflammation by inhibiting the NF-B signaling pathway, while TGR5 activation similarly suppresses macrophage inflammatory responses 164,165,166

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