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TNF- peaked on day 1 in patients with moderate/severe pancreatitis, whereas TNF- peaked on day 4 in patients with mild pancreatitis

This dysbiosis disrupts immune homeostasis by elevating proinflammatory cytokines and compromising immunosurveillance, thereby promoting ectopic lesion survival and growth

To this purpose, the present review aims to discuss the advantages and challenges of using cutting-edge techniques to discover salivary biomarkers which may be used in diagnosis/therapy of several chronic diseases with inflammatory consequences, with the pursuit to possibly replace conventional paths with detectable soluble mediators in saliva

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