In vivo , FTO knockdown significantly elevates YTHDF2 expression in the striatum of PD mice, inhibits m 6 A demethylation of BAP1 and reduces BAP1 expression, upregulates SLC7A11 expression, decreases -Syn, MDA, Fe 2+ , and 4-HNE levels, suppresses neuronal ferroptosis and disruptions in the amino acid antioxidant system, and promotes dopaminergic neuronal survival in PD mice (Li et al., 2025c)
This study paved the way for further research on the extrinsic apoptotic pathway
Neural Progenitor Cells (NPCs): Directly support the regeneration of damaged neural networks in the reticular activating system (RAS) and thalamocortical pathways, reestablishing the natural balance between sleep-promoting and wake-promoting neurons
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