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Notably, NADPH depletion in SLC7A11 high cancer cells results in disulfide stress accumulation and cytoskeleton remodeling, eliciting disulfidptosis under glucose starvation 28

Central to this defense are enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and molecules like glutathione, which collectively neutralize harmful reactive species, safeguard cellular integrity, and support overall cellular function

Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62/Nrf2 signaling

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