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Through its direct influence on cancer cells, increased endothelial dysfunction, and impairment of blood arteries within the tumor, RBP4 increases the metastatic potential of breast cancer tumors ( RBP4 can induce NF-B, and TNF- is known to enhance invasion and metastasis by triggering NF-B signaling, with its expression being higher in 4T1 tumors than in 67NR tumors ( Table 1 )