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Randomized controlled trials (RCTs) report that IF reduces androgen markers, including total testosterone and free androgen index, in premenopausal females with obesity, while producing modest declines in testosterone among lean males without significantly affecting LH secretion [55]

It is under investigation in preclinical and clinical studies on overweight, obesity, and metabolic disorders, where researchers have examined its effects on body weight and energy intake, including when combined with GLP 1 receptor agonists such as semaglutide, but it is not an approved therapy

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