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Differential presentation of tumor antigen-derived epitopes by MHC-class I and antigen-positive tumor cells

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Some community members are running this sequence deliberately: start with NAD+ precursors (NMN/NR) to raise the baseline pool, then add MOTS-C to put that pool to work, then layer in 5-Amino-1MQ to block the pathway that drains it

With a more exposed TIN2 TBM binding site and a native loop conformation adjacent to the site, the new P4 1 2 1 2 crystal system presented an opportunity to obtain more diverse, tractable fragment hits across the TIN2 TBM site, which could facilitate the NMR hit optimisation process through fragment growing, linking, and merging, and provide new hit matter