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Fatigue or drowsiness Due to its role in regulating melatonin and circadian rhythms, some may feel more tired initially

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Zhang et al., 2018), mutations in -Syn proteins undergo misfolding in transcription-translation to produce toxicity, and defective mitophagy further exacerbates neurotoxicity, leading to neuronal loss or damage (Wang et al., 2018)

The discovery of homozygotic risk genes in most of the very rare (probably less than 1%) cases of early onset Alzheimers disease which share increased production of -amyloid (A) as one (but probably not the only one) common property led to the amyloid-cascade hypothesis, assuming A as the major if not the only causative factor for the development of AD