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Inhibition of the glutamate forming enzyme glutamate carboxypeptidase II (GCP II), may help prevent both peripheral and central nervous system damage during chemotherapy and has been proposed as a possible treatment for amyotrophic lateral sclerosis (ALS), stroke, and even Multiple Sclerosis plus other neuropsychiatric diseases (Rahn et al, 2012)
Targeted degradation of LRG1 to attenuate renal fibrosis
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