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Current research indicates that autoantibodies, innate immunity, adaptive immunity and cytokines are involved in the regulation of melanocyte destruction or apoptosis, which is the main mechanism leading to the pathogenesis of vitiligo 17

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[PubMed: 15068826] (Review of efficacy and safety of kava concludes that hepatotoxicity is an idiosyncratic reaction and that the risk-to-benefit ratio of kava extracts remains good in comparison to other drugs for anxiety)