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That is a very different statement from they do nothing. It means: The mechanistic rationale is real

These issues can make even the simplest recovery feel like a significant obstacle

Acknowledgements This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT (NRF-2021R1A2C1005368), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (RS-2023-00217123), and the Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program (KGM5192423 and KGM9942522)

Articles that did not involve or discuss about patients with pernicious anemia treated with oral vitamin B12 replacement were excluded