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Lipoic acid biosynthesis defects

Its antioxidant properties help protect skin cells from damage caused by environmental stressors such as pollution and UV exposure

Fluoroquinolone exposure tends to suppress the TCA cycle and activate the glyoxylate shunt, conserving carbon and reducing ROS while channeling electrons into NADPH/GSH synthesis

We hypothesize, that dysregulation of glutaminolysis using CB-839 may overcome drug resistance in CLL cells and be an effective treatment strategy when used alone or in combination with agents that inhibit pathways responsible for survival, proliferation, and migration of CLL lymphocytes