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Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis ( 3.5.4 Gut microbiota-based therapeutic interventions 3.5.4.1 Probiotics Given these findings, probiotic supplementation, particularly with strains of Lactobacillus and Bifidobacterium , has shown potential to restore microbial balance, enhance SCFA production, and reduce inflammation in CFS/ME patients (Skjevling et al., 2024)

Decreased oxidative stress could be an important mechanism whereby glycemic control diminishes the incidence of diabetic microvascular complications (9,10)

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There is a higher chance of damage in digestion, which can cause bloating, or nausea, particularly at high doses