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Since acidosis is a hallmark of inflammatory processes as well as a crucial determinant of tumor progression, resulting from the increased glycolysis and the subsequent accumulation of lactic acid as well as the massive production of protons [83], glutamine supplementation may help to reduce inflammation in cancer cachexia patients by maintaining pH homeostasis in the body via ammonia (NH 3 ) transport between tissues [5,84]

Future research should focus on large-scale, well-controlled randomized trials with standardized dosing protocols, clearly defined deficiency thresholds, and long-term follow-up to strengthen the evidence base and guide clinical practice

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The FDA has issued warning letters to vendors selling injectable BPC-157 as a consumer product