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In DSS and TNBS induced colitis models, orally administered KPV has consistently reduced disease activity scores, lowered inflammatory cytokine levels, decreased mucosal damage, and helped restore gut barrier function

doi: 10.1016/j.neuron.2018.06.030 55 ElliottC.MomayyezsiahkalP.ArnoldD

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The 1R ligand mediates the generation of new synapses and dendritic spines through the mitogen-activated protein kinase/extracellular regulated kinase and PI3K/AKT signaling pathways, thereby exerting neuroprotective effects [154]