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Acknowledgements We wish to thank Dr Carlos Ardavin, Dept

Analysis of Central Nervous System Karyopyknotic Cells Modified Bielschowskys silver staining and KlverBarrera staining (using KlverBarrera Luxol fast blue) were performed to demonstrate argentophilic neurites, axonal spheroids, and neuronal cell bodies, particularly in brain karyopyknotic areas ( (file:/ The brain was dissected according to NTP-7 at Levels 3 and 6 with neuroanatomic subsites presented in certain brain sections using coronal sections with three mandatory sections (Eustis et al., 2017

Its overactivation disrupts nicotinamide metabolism, reduces NAD+ levels, promotes hepatic lipid accumulation and lipotoxicity, and represents an important therapeutic target for hepatic metabolic disorders