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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]

Another class of gastric acid inhibitors known as histamine 2 (H 2 )-receptor antagonists (e.g., cimetidine, famotidine, and ranitidine), often used to treat peptic ulcer disease, has also been found to decrease the absorption of vitamin B 12 from food

Most therapeutic peptides are rapidly cleaved by gastric acid and luminal proteases (pepsin, trypsin, chymotrypsin) before meaningful absorption can occur

[3] Seiwerth, S., Brcic, L., Vuletic, L.B., & Sikiric, P