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We discovered a first-in-class inhibitor of the TRF1:TIN2 interaction (compound 40 ) that binds to TRF1 TRFH with a K D of 29 M (95% CI: 2041 M), displaces a TIN2 probe with an IC 50 of 67 M (95% CI: 10120 M), and expels TRF1 from purified shelterin

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