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Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B 12 and folic acid on fracture incidence

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Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca 2+ in the endoplasmic reticulum