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A growing body of preclinical research suggests that targeting the ferroptosis regulatory pathway centered on GPX4, including drug inhibitors, natural active compounds, gene or RNA intervention strategies, and novel local delivery systems, can alleviate cartilage degeneration and joint inflammation to varying degrees in experimental OA models

DSIP has been investigated in controlled human sleep studies, showing effects on sleep duration, sleep stage distribution, and subjective sleep quality, making it relevant to research on sleep regulation, stress modulation, and recovery

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