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It is most relevant during GLP-1 use or caloric deficit, when fatigue is part of the picture, with age-related NAD+ decline, or when progress stalls after a clean first month

[3] Iron is not absorbed as well when taken with calcium or calcium-containing foods like dairy, or with foods high in oxalates (such as spinach, kale, beets, rhubarb, chocolate, nuts, and wheat bran)

The combination has been associated with elevated sirtuin activity, altered adipocyte differentiation markers, and changes in muscle stem cell quiescence and proliferation in the cited preclinical literature

[DOI] [PubMed] [Google Scholar] Castelli MC, Wong D, Friedman K, Bhargava P, Riley GM