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Figure 1 2.1 Tumor-associated macrophages and endothelial cell crosstalk Tumor-associated macrophages (TAM) are one of the most represented populations of myeloid cells in the TME (36, 37)

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Redox reactions typically utilize the biologically accessible oxidization states of the metal core to transfer electrons to naturally occurring substrates that are essential for the cancer cell metabolism and therefore induce cell death