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Moreover, the authors performed q RT-PCR to quantify Nrf2 mRNA expression, demonstrating that quercetin upregulated this key antioxidant transcription factor while restoring endogenous antioxidant enzyme activity and reducing tissue damage (Sharma et al., 2020

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Moreover, NiH supported the immunosuppression in CIA mice, as indicated by the reduced production of pro-inflammatory cytokines, along with a decrease in the proportions of pro-inflammatory cells and an expansion of immunomodulatory cells (101)