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[,,] While it is known that there are multiple adverse effects that are related to the use of EDTA, CaNa 2 EDTA is known to have fewer adverse effects compared to Na 2 EDTA and has become the general chelating agent for clinical use that is able to react with a wide variety of metal ions

Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, et al

Englert C, Trutzschler AK, Raasch M, Bus T, Borchers P, Mosig AS, et al

Another advantage of using a biomaterial scaffold as opposed to traditional administration routes such as IV is that the drug delivery is more localized, meaning that there is less accumulation of the drug in areas other than directly at the tumor site, constituting less damage to healthy tissue and thus reducing adverse effects ( 4.1.1 Impact of chemotherapy on the TME Chemotherapy drugs target many aspects of cell physiology, including DNA replication, RNA synthesis, cell structure and metabolism