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Furthermore, a similar results were reported in a study of individuals with or without oligozoospermic which showed no significant association between DNA methylation in spermatozoa and the MTHFR C677T genotypes although a trend for higher incidence of methylation alterations in severe oligozoospermic infertile men with CT genotypes were observed 34 , suggesting that a much more complicated or indirect interactions between MTHFR polymorphism and methylation are involved

Anti-inflammatory and antioxidant actions Chronic low-grade inflammation and oxidative stress can damage follicles and contribute to miniaturisation

Thompson, Eric McLaughlin, Chien-Wei Chiang, Hisham Hussan The Cancer Journal.2024

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