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The peptide's pro-angiogenic and pro-mitogenic mechanisms that make it attractive for tissue repair are the same mechanisms that generate concern about tumor biology, aberrant vascular remodeling, and endocrine interference

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Phase 2 trial (Lancet 2021) tested cagrilintide 0.3 mg through 4.5 mg/week as monotherapy and reported a clear dose-response, with 10.8% mean weight loss at 4.5 mg/week at 26 weeks

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