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L-carnitine reduces muscle cramps in patients with cirrhosis

Biomaterials 35 , 50415048 (2014)

The tolerogenic mechanism is elegant: by presenting histone epitopes in a context that promotes regulatory rather than effector T cell responses, these peptides essentially re-educate the immune system to tolerate its own nuclear components

BMSCs face replicative senescence, exhibiting progressive shortening of chromosomal telomeres, reduced stemness and a heightened risk of mutation ( ex vivo cellular ageing ( ex vivo study also revealed a dramatic decrease in the potential for hepatic differentiation at later passages (passage 8, p8) ( 4 Homing functions of MSCs in ALF treatment Homing to damaged tissue sites is a key property of BMSCs in treating liver failure