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as a result, renal ammonia production contributes to systemic hyperammonemia [49]

Recent (albeit modest) successes with amyloid-clearing immunotherapies suggest that reducing the load of potentially pathogenic oligomers or higher-order aggregates may be beneficial, and at the same time provides proof-of-principle that these species are at least partially responsible for promoting the degenerative process (Jucker and Walker, 2023)

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