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The research specifically shows that stressing out rats with mild stressors for 40 days causes increases in oxidative stress, including increases in SOD (superoxide dismutase).[ref] (We will return to SOD in a minute.) How does the dysregulation of the HPA axis and altered cortisol levels cause mitochondrial dysfunction

The key is patience and consistencymost people notice significant improvements in their dark spots after 8-12 weeks of regular use

antioxidants (vitamin E, ascorbic acid) to intercept free radicals