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Despite its prevalent use in chemotherapy, 5-FU monotherapies are reported to have significant toxic effects on heart [3]

This represents the absolute maximum daily intake unlikely to cause adverse health effects, specifically benchmarked against the prevention of liver damage

SARS-CoV-2 mainly destroys pulmonary surfactant-secreting type II alveolar cells (Wang et al., 2021a), that normally decrease the air/tissue surface tension and block TLR4 in the lungs, promoting ARDS and inflammation

Consequently, these compounds have not undergone systematic and standardized experimental pharmacokinetic research on new drugs