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Category 2 includes substances that raise significant safety or efficacy concerns, meaning they generally cannot be used in compounding unless specific criteria are met

The study excluded individuals who consumed alcohol or caffeine beyond recommended daily limits, those who smoked, were pregnant or lactating, had used supplements or energy drinks with taurine or B vitamins in the 30 days before enrollment, or suffered from sleep disorders

no serious adverse events observed

In a randomized controlled trial of 72 patients with type 2 diabetes and reduced heart rate variability, oral supplementation with 800 mg/day of lipoic acid for four months resulted in significant improvement in two out of four measures of heart rate variability compared to placebo (81)