ARBs down regulate pro-inflammatory transforming growth factor-beta (TGF-), increased in LC (Mahudpour et al., 2020), CFS (Yang et al., 2019), AD (Zhang et al., 2016), Marfan Syndrome, and EDS
Younger adults with accelerated aging from stress: Prevents premature decline
Paradoxically, liver-specific FASN knockout promoted hepatic steatosis in mice on a zero-fat diet [60], in which steatosis developed alongside defective PPAR signaling and with a phenotype that could be corrected by dietary fat or a PPAR agonist [60]
It promotes lipolysis , the breakdown of triglycerides into free fatty acids used for energy, aiding in reductions in body fat percentage (Yaspelkis & Ivy, American Journal of Physiology )