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Therefore, they recommended that more studies should be conducted to investigate the effectiveness of new therapeutic approaches based on thiol-containing compounds, such as alpha-lipoic acid and N-acetylcysteine (146)

Open questions also include an unresolved debate in the peer-reviewed literature about the implications of BPC-157s pro-angiogenic activity for cancer-relevant signaling pathways, raised in a 2025 literature review and disputed by the original research group

Disagreements were resolved through discussion or consultation with a third reviewer