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39,40 Elevated phosphoribosyl pyrophosphate (PRPP) synthetase activity and deficiency in hypoxanthine phosphoribosyl transferase (HPRT) not only enhance endogenous purine synthesis but also result in excessive production and buildup of uric acid

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Generally well-tolerated at standard doses

Children born via assisted reproductive techniques, especially in vitro fertilization with intracytoplasmic sperm injection, have been noted to have higher rates of birth defects than children born via natural conception, but it is still not known whether this reflects problems caused by abnormal sperm, laboratory processing, or other factors