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This is then condensed by Arg1 with aspartate to form argininosuccinate which is then cleaved to fumarateone of the TCA cycle intermediates

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Research efforts are urgently needed to elucidate the complex mechanisms underlying fluconazole resistance, particularly in emerging Candida species, to inform targeted therapeutic interventions and mitigate the growing impact of antifungal resistance in clinical settings [6]

This scenario affects hundreds of thousands of pregnancies annually