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Consistent with Oga deletion, pharmacological inhibition of Oga, which induces acute elevation of O-GlcNAcylation, has been shown to attenuate hippocampal activity by diminishing the intrinsic excitability of CA1 neurons and excitatory synaptic transmission at Schaffer collateral-CA1 synapses [80]

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These agents have transformed the management of both type 2 diabetes and obesity, offering benefits beyond glycemic control

Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) were used via the R package clusterProfiler to analyze potential pathway related to DEGs between low and high expression gene sets, and visualized with the OmicShare tool ( an online platform for data analysis